Application Note: A Three-dimensional Investigation of Cell and Plaque Interactions in the Alzheimer’s Diseased Brain

Amyloid beta plaques are a hallmark of Alzheimer’s disease, but studying them can be challenging when constrained to two dimensions. Plaques range from 10 µm to 120 µm in diameter, which means that most techniques fail to capture the entire plaque in a single analysis.

With 3D spatial multi-omics, this is no longer out of reach. 

This approach gives scientists the ability to:

• Probe cell-plaque relationships
• Quantify plaque volumes
• Analyze adjacency of specific cell types to plaques

In this Application Note, we show how 3D spatial multi-omics can visualize entire plaques alongside key cell populations in the brain.