Beyond Dissociation: What Single-Cell Sequencing Still Can’t Tell You

Cellular atlases built from single-cell RNA sequencing have transformed biology — but dissociating cells erases the spatial relationships that drive disease. Single-cell RNA sequencing (scRNA-seq) has done more to map cellular complexity than almost any technique of the last decade, producing comprehensive atlases of healthy and diseased tissue across organ systems. But traditional transcriptomic analysis […]