True 3D Perspectives
The Stellaromics blog
3D Spatial Multi-Omics: The Next Dimension of Tissue Biology
Conventional spatial biology methods rely on thin, 5–10 μm tissue sections. But even following computational reconstruction these thin tissue slices strip away the true three-dimensional context of cell-cell interactions. 3D spatial multi-omics takes a different approach: rather than reconstructing thin
Rebuilding the Kidney in 3D: A New Map of Nephron Cell Types In Situ
A 64-gene panel resolves the kidney’s specialized cell populations directly within intact, thick tissue — no dissociation required. Single-cell RNA sequencing has done more to map the kidney’s cellular complexity than perhaps any technique of the last decade. By profiling
The Hidden Cost of Thin Slices: What 2D Tissue Sections Are Quietly Undercounting
Decades of standard histology have systematically underestimated cell density, proximity, and tissue complexity — the data show exactly how much. For decades, spatial biology and histology have relied on a simple convention: cut tissue into thin (5–10 μm) sections, mount
Beyond Dissociation: What Single-Cell Sequencing Still Can’t Tell You
Cellular atlases built from single-cell RNA sequencing have transformed biology — but dissociating cells erases the spatial relationships that drive disease. Single-cell RNA sequencing (scRNA-seq) has done more to map cellular complexity than almost any technique of the last decade,