Rebuilding the Kidney in 3D: A New Map of Nephron Cell Types In Situ
A 64-gene panel resolves the kidney’s specialized cell populations directly within intact, thick tissue — no dissociation required. Single-cell RNA sequencing has done more to map the kidney’s cellular complexity than perhaps any technique of the last decade. By profiling the transcriptomes of thousands of individual cells, researchers have built comprehensive atlases of healthy and […]
The Hidden Cost of Thin Slices: What 2D Tissue Sections Are Quietly Undercounting
Decades of standard histology have systematically underestimated cell density, proximity, and tissue complexity — the data show exactly how much. For decades, spatial biology and histology have relied on a simple convention: cut tissue into thin (5–10 μm) sections, mount it on a slide, and image what’s there. It’s fast, standardized, and built into nearly […]
Beyond Dissociation: What Single-Cell Sequencing Still Can’t Tell You
Cellular atlases built from single-cell RNA sequencing have transformed biology — but dissociating cells erases the spatial relationships that drive disease. Single-cell RNA sequencing (scRNA-seq) has done more to map cellular complexity than almost any technique of the last decade, producing comprehensive atlases of healthy and diseased tissue across organ systems. But traditional transcriptomic analysis […]